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The challenge lies in the fact that both Graves' disease itself and its treatments affect appetite regulation, metabolism, and insulin sensitivity

Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study

Targeting Cholesterol Absorption Lowering cholesterol absorption from the intestines reduces LDL cholesterol in a different fashion

However, their effectiveness is limited by stability, bioavailability, and targeted delivery to the gut