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Increasing evidence has suggested that cancer cells can enter a reversible drug-tolerant persister state to survive chemotherapy or targeted agents

Domen HM, Hwa V, Jasper HG, Rosenfeld RG

Butyrate-modified drug delivery: enhancing bioavailability and targeted therapy via transporter exploitation Monocarboxylate transporters in butyrate absorption and targeted drug delivery systems In the intestinal lumen, butyrate mainly exists in an ionized form and necessitates specialized transmembrane transporters for cellular uptake [1, 76]