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Intraperitoneal, but not intracerebroventricular, administration of INSL-5 dose-dependently increases food intake in mice, indicating the peptide may exert its orexigenic effect by acting on peripheral targets, rather than via the CNS (164)

If pregnancy occurs while taking tirzepatide, discontinue immediately and inform your obstetrician

Include whole grains, legumes, nuts, seeds, fruits, and vegetables Watch for fiber tolerance, especially if appetite or gastric emptying is reduced Electrolytes & Hydration Slower gastric emptying can increase nausea and dehydration risk

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