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2.2 ApoE production, lipidation, and impact of ApoE isoform on receptor binding ApoE production and secretion are highly specific to particular cells and tissues (Fernndez-Calle et al., 2022

doi:10.1089/dia.2019.0185 Brayden DJ, Hill TA, Fairlie DP, Maher S, Mrsny RJ

This led to a focused research program that ultimately produced PT-141

17,173,184,190 The prognosis for DRPN is generally favorable, with many patients experiencing significant recovery over months to years, although some may have residual weakness, particularly with early diagnosis and appropriate management