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In parallel, chronic ethanol exposure in mice impairs dendritic cell presentation of exogenous antigens through MHC II and alters costimulatory profiles, leading to diminished antigenspecific Tcell activation despite largely preserved MHC I crosspresentation (54)

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And we know now that inflammation plays a big role in major depressive disorder and depression not in all cases, but theres a subset where it really does seem to play a big role

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