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Taking a vitamin B complex is recommended because there is evidence that a combination of neurotropic B vitamins is more effective than taking a single vitamin B supplement, due to the synergies between the different vitamins.

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Patients with OA exhibit elevated iron levels in synovial tissue, and the impairment of iron homeostasis-regulating genes causes cellular iron accumulation, resulting in heightened production of ROS as well as the increased level of collagen II and MMP13, which are established hallmarks of OA [85] (Figure 2)