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Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy

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These diseases can lead to a variety of related diseases, including cardiovascular disease and cancer, which impose great burdens to health system worldwide

2.1 Trimethylamine-N-oxide and betaine in humans In humans, TMAO is mostly biosynthesized from the unabsorbed dietary constituents containing trimethylamine moiety such as choline (concentrated in egg yolk and liver) and L-carnitine (predominantly in red meat) through the activity of inhabitant bacteria of the human large intestine (Li et al., 2018a) (Figure 2)