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J Exp Clin Cancer Res Dual CDK and MEK Inhibition potentiates CD8+ T cell-mediated antitumor immunity by inducing pyroptotic cell death in high-mutational head and neck cancer

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SREBP-1, in particular, governs the transcription of various lipogenic enzymes, including ACC, FASN, and glucose-6-phosphate dehydrogenase (6PGD), thereby playing a critical role in fatty acid biosynthesis [25]