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58 Median time to the development of a full symptom complex of frequency, urgency, and pain was reported to be two years in one study

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Multiple other causes should be considered including peripheral vascular disease, neuropathy, medication effects from other drugs (particularly diuretics, beta-agonists, and statins), hypothyroidism, pregnancy, and musculoskeletal conditions

It has a strong affinity for copper ions, which are essential cofactors in enzyme processes related to tissue maintenance and repair

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