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Presently, the drugs available for treatment, including crizotinib or erlotinib, are tyrosine kinase inhibitors (TKIs) for cancer treatment (primarily lung adenocarcinoma), exhibiting EGFR mutations or EML4-ALK fusions

Ethics Approval and Consent to Participate The study was approved by the Ethics Committee of Shijiazhuang Peoples Hospital (Approval No: 2025075)

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Recent studies using perfused rat kidneys have shown that boldine induces vasodilation of renal arteries in a dose-dependent, endothelium-dependent manner, with effective doses ranging from 30 to 300 nmol

Medicinal research reviews, 43: 1668-1700 (2023) Wright JW, Kawas LH, Harding JW Progress in neurobiology, 125: 26-46 (2015) Desole C, Gallo S, et al