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It was initially shown that in drug addicts, who were accidentally exposed to MPTP, there was a depletion of pigmented nerve cells in the substantia nigra, accompanied by astrogliosis and clustering of microgliosis around nerve cells [41], thus presenting some PD-like features

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The glyoxalase I and II which are responsible for catalyzing the conversion of methylglyoxal (a by-product in glycolysis) to lactic acid are among these enzymes [76]