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In patients with Leber's disease, administration of cyanocobalamin may cause acute and rapid atrophy of the optic nerve

After twelve weeks of administration, a dose-dependent weight loss of -5.5, -6.9, -10kg, respectively, was reported, vs -0.4kg in the placebo group

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Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency

Make sure they dont touch each other, which could make them freeze early