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Acknowledgement The patient in this manuscript has given written informed consent to the publication of his case details and photographs

We found that melatonin treatment precipitated major transcriptomic shifts in ILC2s whereby genes encoding the key enzymes in glycolysis ( Figure 5E ) and the TCA cycle ( Figure 5F ) were expressed at demonstrably lower levels compared to controls

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According to melasma researcher AJ Pandya, the most effective treatment approach is a combination of various topical and in-office therapies