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Alternative approaches are also being explored to improve fertility outcomes, such as aspirin (Phase III), the osteoporosis drug alendronate (discovery) or the neurologic medication cabergoline to prevent ovarian hyper syndrome (Phase III)

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Patients assigned to tirzepatide showed a 20.9% BW loss after 36 weeks with an additional 5.5% reduction after 52 weeks, while those who switched to placebo experienced a 14% weight regain, confirming the findings from STEP 4 supporting the chronicity of obesity and the need for continuous treatment