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Although genetic predisposition is likely to play a significant role in development, there is growing evidence suggesting that microbial translocation across the intestinal barrier may contribute to the pathogenesis of SLE

This relatively long half-life is a result of the medication's structural modifications, particularly its binding to serum albumin and resistance to enzymatic breakdown

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Int Biodeterior Biodegrad 65:733743 Ferraz ERA, Umbuzeiro GAG, Caloto-Oliveira A, Chequer FMD, Zanoni MVB, Dorta DJ, Oliveira DP (2011) Differential toxicity of disperse red 1 and disperse red 13 in the Ames test, HepG2 cytotoxicity assay, and Daphnia acute toxicity test