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10.3390/cancers14082043 77 FilippF

Glutathione serves as a cofactor for glutathione peroxidase (GPX4), an enzyme responsible for breaking down the accumulation of lipid reactive oxygen species

Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesis

For example reactions requiring GSH as a key cofactor are catalyzed by the prostaglandin H synthase, the rate-limiting enzyme in the production of prostaglandins and thromboxane [25], which are essential regulators of vascular function

That model is connected to the model for APAP metabolism described here by adding the reaction by which GSH conjugates NAPQI via the enzyme GST