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Who Makes a Good Candidate for GLP-1 Medications

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Hanna SC, Krishnan B, Bailey ST, Moschos SJ, Kuan PF, Shimamura T et al

While chronic exposure to GLP-1Ra appears to be essentially neutral on both systolic and diastolic function, irrespective of left ventricular ejection fraction (LVEF), a beneficial impact of SGLT-2i is consistently detectable for both systolic and diastolic function parameters in subjects with diabetes with and without HF, with a gradient proportional to the severity of baseline dysfunction

However, their effects on bone integrity remain complex, with some evidence indicating bone-protective mechanisms while others suggest potential increases in bone resorption associated with weight loss