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Additionally, the IGF-1/IGFBP-3 ratio, a common rough of free IGF-1 levels, is significantly decreased in obesity [216], however no IGF-1 bioactivity was estimated

Two studies using vildagliptin and sitagliptin have examined the impact of DPP4 inhibition on the kidneys of hyperglycemic animal models, demonstrating renoprotective effects

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