Retrograde menstruation, ectopic bleeding, and erythrocyte degradation lead to iron overload, which increases the cytoplasmic iron pool
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For example, patients with systemic primary carnitine deficiency (SPCD) have a deficiency in carnitine due to a mutation in the plasma membrane sodium-dependent high affinity carnitine transporter (OCTN2) that enables cellular carnitine uptake in the heart, muscle, and kidney
For example, MT-1A and MT-2A and the misbalance of metal levels were associated with metabolic syndrome pathologies such as diabetes, high blood pressure, dyslipoproteinemia, atherosclerosis, etc
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