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In addition, a case-control study reported that the A allele was more prevalent in individuals affected by Hashimoto thyroiditis (HT) a T-cell-mediated autoimmune disease resulting in the destruction of thyroid cells than in healthy controls (37)

Abbreviations RIP: Radiation-induced proctitis ROS: Reactive oxygen species EGCG: Epigallocatechin gallate MPO: Myeloperoxidase CD68: Cluster of differentiation 68 TNF-: Tumor necrosis factor-alpha IL-6: Interleukin-6 IL-10: Interleukin-10 MDA: Malondialdehyde SOD: Superoxide dismutase GPX: Glutathione peroxidase ZO-1: Zonula occludens-1 PCA: Principal component analysis DEGs: Differentially expressed genes GO: Gene ontology MAPK: Mitogen-activated protein kinase Rap1: Ras-associated protein 1 References Colorectal Surgery Group, Colorectal BoSCMA, Surgeon Committee SBCMDA

Modern studies have revealed that BBR, the primary active component in Coptis chinensis, and its mechanism of regulating glucose and lipid metabolism are just scientific confirmation of the theory of clearing heat to restore qi transformation in TCM

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