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As weight decreases and energy improves, physical activity becomes easier and more appealing, creating a positive feedback loop

Activation of G_s proteins facilitates the accumulation of cAMP within AP^Glp1r neurons, while G_q signaling is linked to intracellular calcium fluxes

Some research suggests tirzepatide users may experience fewer severe GI side effects than expected given its dual mechanism, but responses are highly individual

Int J Neurosci 133(5):473491