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Clinical studies supporting the role of GLP-1 in weight loss GLP-1 agonist and weight loss In a STEP 1 clinical trial, semaglutide, a GLP-1 RA, demonstrated an average weight loss of 15% to 17% over 68 weeks when combined with lifestyle changes

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In a large Chinese cohort of patients with CHB infection, metabolic syndrome was independently associated with an approximately two-fold increased risk of HCC after adjustment for age, sex, smoking, alcohol use, cirrhosis, and AST levels (91)

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doi: 10.1186/s40478-021-01180-z 229 YangYZhangJMaDZhangMHuSShaoSet al