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Pharmacological and procedural escalation was then typically layered on top of this foundation, with topical NSAIDs prioritized for knee pain, oral NSAIDs considered when appropriate, and intra-articular corticosteroid injections used for persistent symptoms ( This framework was not without evidence

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The EMPEROR-Preserved trial made history as the first successful trial for heart failure with preserved ejection fraction (HFpEF), a condition previously considered untreatable