Yes, mild reductions are often observed
Cell Metab 10:167177 Lenhard JM, Croom DK, Minnick DT (2004) Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments
SUSTAIN-6, conducted in patients with type 2 diabetes, showed a 26% reduction in major adverse cardiovascular events (heart attack, stroke, or cardiovascular death) with semaglutide compared to placebo
Interestingly, in trajectory 3 after 750 ns, the dynamic ECD moves back toward the TMD and is stabilized in a conformation that forms contacts mainly with ECL1, resembling the closed ECD conformation in the crystal structure
The genetic test reveals whether you carry variants associated with higher or lower GLP-1 receptor expression, stronger GIP signaling, or metabolic predispositions that influence appetite and weight regulation