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For example, deferiprone (DFP) and PBT2 have been shown to increase endothelial tight junction protein expression in AD models, reduce vascular leakage, and improve BBB integrity, suggesting an indirect BBB-protective potential (Ayton et al., 2025)
That signal comes from caloric deficit, glucagon elevation during fasting, or pharmacological intervention like GLP-1 agonists
The NADPH Connection The most direct link involves NADPH (the phosphorylated version of NAD+)
ImmunoInformatics 16 , 100045 (2024)
doi: 10.1038/s41392-021-00678-1 369 WangC.AcostaD.McNuttM.BianJ.MaA.FuH.et al
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