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These include: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite (which, while contributing to weight loss, can occasionally be excessive) These effects were generally mild to moderate in severity and occurred most frequently during the dose-escalation phase

Triple-hormone-receptor agonist retatrutide for obesity, a phase 2 trial

PubMed, Martchenko, Alexandre, and Patricia Lee Brubaker

The protein priority and timing synergy One final timing consideration that ties directly to outcomes: protein intake timing relative to your injection schedule

If you take one of those, your A1c and glucose are worth tracking closely so your clinician can adjust the rest of your regimen