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Vitamin C typically shows visible improvements in skin brightness and tone within 4-12 weeks of consistent daily application

Mice were subjected to 1% pentobarbital general anesthesia (50 mg/kg intraperitoneal) on days 7, 14, and 21, respectively, and then cardiac blood and dorsal skin tissues were collected (Figure 1)

Interestingly, a recent study reported that LOXL3-mediated deacetylation/deacetylimination abolished the transcription activity of STAT3, thereby inhibiting differentiation of nave CD4 + T cells toward Th17/Treg cells (regulatory T cells) during inflammatory responses (Ma et al., 2017)