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When erastin acts on lung cancer A549 cells, it upregulates and activates P53, thereby transcriptionally activating its downstream target genes (including P21 and bax), thereby inhibiting SLC7A11 activity, inducing ROS accumulation and eventually leading to ferroptosis 48

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Two choice sets compared profiles based on orally administered semaglutide 7 mg or 14 mg with a profile based on dulaglutide 0.75 mg (PIONEER 10), and two choice sets compared profiles based on orally administered semaglutide 7 mg or 14 mg with a profile based on liraglutide 0.9 mg (PIONEER 9)