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Both routes activate identical GLP-1 pathways, but injection typically reaches target tissue faster and requires dosing only once weekly

Severe or persistent vomiting requires immediate attention due to dehydration risk, potential medication malabsorption, and risk of acute kidney injury

IGF-II may also contribute considerable to postnatal growth although the absence of endocrine effects makes it difficult to study in humans

There are a few contraindications: People with family history of medullary thyroid cancer or a rare genetic syndrome called MEN2 should not take GLP-1s, for instance

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