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In preclinical models and early human pharmacology work, ipamorelin stimulates GH release from pituitary somatotrophs via GHS-R1a agonism while producing minimal secondary release of adrenocorticotropic hormone (ACTH), cortisol, or prolactin

9 Deprescribing medications for other conditions Weight loss achieved through the use of medications may make it possible to deprescribe or adjust prescriptions for other medications

Introducing the 8-Month Metabolic Reset Programme This reset is not a fad diet or quick fix

every 50 to 53 days Every 3 months: refill is processed approx

10.1016/j.ymgme.2015.09.004 Mol Genet Metab