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Genetic variants in pathways governing lipid metabolism (including APOE status) and insulin sensitivity influence how aggressively you may tolerate or benefit from lipotropic therapy

The FDA specifically advises against using Zepbound in such cases: "ZEPBOUND is not recommended in patients with severe gastroparesis." FDA Prescribing Information Gastrointestinal side effects, particularly during the dose escalation phase, are common

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doi: 10.3389/fphys.2020.00914, 80 LongH.ZhuW.WeiL.ZhaoJ

Currently, there's limited research on GLP-1 medications during pregnancy, so more studies are needed to fully understand potential risks