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Due to the orthophosphoric groups, these agents can dissociate to form anions with charges of -1, -2, or -3

Diab Care 2011

The FDA has approved these agents for type 2 diabetes management (not type 1 diabetes or diabetic ketoacidosis), with select formulations also approved for chronic weight management in adults with obesity or overweight with weight-related comorbidities

414 Intraperitoneal or intravenous administration of inorganic HS donors, such as sodium sulfide and sodium hydrosulfide, 415,416,417 allows for site-specific delivery