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The findings provide crucial data, according to the researchers, to inform ongoing discussions about balancing the sustainability of health care spending against improving accessibility and affordability of GLP-1 RA medications moving forward. The trend directly informs current debates surrounding insurance coverage policies for weight-loss treatments, highlighting the challenge of reconciling costs with clinical demand and benefit

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a RWD: real-world data from cohort or registry studies (electronic health records, insurance-claims databases), b SRS: adverse drug reaction evidence from case reports and spontaneous-reporting systems, such as the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) and World Health Organization (WHO) VigiBase

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