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Kumar S (2020)

Imbalances in BA influence disease progression through multiple mechanisms (1): modulating hepatic urate production via PPAR-/XOD signaling (2), regulating immune responses through FXR/TGR5-dependent suppression of NLRP3 inflammasome activation, and (3) shaping the gut microbiota composition, which reciprocally affects uric acid homeostasis and inflammation

High LDH levels may predict a poor response to treatment in people with metastatic disease