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[2] Opposing effects: Melatonin might counteract intended medication effects (e.g., reducing effectiveness of immunosuppressants)

Similarly, control mice with Pcsk9 overexpressioninduced atherosclerosis treated with 10 g/kg semaglutide for 18 weeks also showed reduced liver inflammation, as confirmed by quantitative PCR analysis of Col1a1 , Tnf , Ccl2 , Tgfb1 , Cd3g , Il2 , and Il4 expression (29)

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