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A subungual bleed will normally have arisen within a day or two and may be associated with an episode of trauma, or more commonly, a period of vigorous activity or sport where no trauma is recollected

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The ability of metformin to increase GLP-1 levels independently of effects on DPP-4 suggests there could be a direct benefit in terms of incretin action by combining metformin with DPP-4 inhibitors