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260 GLP-1 downregulated Na+/H+ exchanger isoform 3 in the renal proximal tubule of rats, suggesting that GLP-1 could be used to treat hypertension and sodium retention disorders

If the medication is stopped, appetite can return, and some patients regain a significant amount of weight

In PD clinical trials, the beneficial effects have been observed for only 1 yeara substantially short period considering the lifelong, progressive nature of neurodegeneration

At validated doses, these mechanisms produce predictable metabolic outcomes

In animal studies, some GLP-1s have shown harmful effects on developing foetuses, which has led to caution around use in pregnancy and breastfeeding