Pro-regenerative signaling after acetaminophen-induced acute liver injury in mice identified using a novel incremental dose model
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Research has demonstrated that Dihexa binds to HGF with remarkably high affinity (Kd = 65 picomolar) and acts as an allosteric modulator, potentiating HGF activity even at subthreshold concentrations
At a later stage, MET is predominantly pre-synaptic, reflecting a dynamic regulation of MET expression depending on the post-natal age of the examined mice ( FIGURE 2 The pMET protein levels peak at P7P14 in the neocortex, a period corresponding to synaptogenesis and dendritic outgrowth, and are downregulated during the 3rd post-natal week, between P14 and P17, when pruning and functional synapse maturation occur ( Rhesus monkey) (Judson et al., 2011) reveals a similar temporal expression pattern of MET as in rodents, with peak levels corresponding to the same periods detected in mice and rats
However, in other cases, when mechanisms do not align with the chemistry, more detailed analysis is required
