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They are rapidly inactivated to GLP-1 (9-36) amide and GLP-1 (9-37) by DPP-IV within a few moments in blood

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When to Get Help Seek medical attention for severe or persistent symptoms or any concerning reactions

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They can lose such a significant amount of weight in such a short period of time that they develop complications from starvation and have to be hospitalized. Nagata suggests that patients taking GLP-1s check in regularly with a physician or nutritionist who can monitor their progress and flag unhealthy behaviors