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Nonetheless, hypoxia-induced stabilization of HIF is essential for intestinal homeostasis owing to its regulatory role in the transcription of barrier-protective genes, mucin secretion, antimicrobial peptide synthesis, nucleotide signaling, iron metabolism, and metabolic genes including hexokinase, lactate dehydrogenase, pyruvate kinase, aldolase, phosphofructokinase, and phosphoglycerate kinase, among others 73,80

[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Eisele P.S., Furrer R., Beer M., Handschin C

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