JACC Clin Electrophysiol 4(1):116
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In short-term fasting studies (812 h), reductions in IGF-I are generally modest and sometimes not statistically significant, whereas longer fasting periods or severe energy restriction can lead to substantial and significant decreases in IGF-I [68]
Equally important is a thorough regulatory due diligence at the pre-market stage, as gaps in product characterisation, safety data, or substantiation strategy can significantly increase the risk of costly delays, requests for additional information, or ultimately a negative regulatory outcome
Avoid lying down immediately after meals, which can worsen symptoms related to delayed gastric emptying