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Safety data in humans is limited, and therapy should only be considered under licensed medical supervision though research is still ongoing

doi: 10.1038/ni.2416 23 GaublommeJTYosefNLeeYGertnerRSYangLWuCet al

Operates within physiologic energy homeostasis systems: Energy balance is maintained by coordinated signaling among leptin, insulin, GLP-1, ghrelin, and amylin

"A balanced vegetarian diet with dairy products seems to be the most protective diet for kidney stone patients"

Overall, Zepbound appears to be associated with a lower overall rate of reported adverse events while delivering greater average weight-loss efficacy