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After 3 days, striatal GCL activity was significantly higher in mice injected with mito GCL than in those injected with inactive mito GCL (E103A), whereas striatal GSH concentrations remained unchanged (Fig

The lower levels of GSH can be attributed to various factors, such as a lack of LC in the diet, increased production of ROS and oxidative stress caused by the consumption of an energy-rich diet, and/or increased utilization of GSH compared to its biosynthesis

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While GLP-1 and GIP primarily manage glucose and appetite, the glucagon receptor agonism adds a powerful new dimension

Additionally, F.R