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The alterations and breakdown of functional components of the BBB can occur naturally with aging even in the absence of underlying conditions that cause cognitive decline and dementia [51]

Liraglutide, a GLP-1 receptor agonist (GLP-1RA), was shown to reduce serum total cholesterol, LDL-C, high-density lipoprotein cholesterol (HDL-C), and TG levels by decreasing hepatic LDLR and PCSK9 expression in db/db mice, but not in wild-type mice [16]

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