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We framed the research question based on the PICO approach: Population (adult with overweight or obesity) Intervention (once weekly subcutaneous tirzepatide 5, 10 and 15 mg) Control (placebo or GLP-1 RAs) Outcome (absolute change in weight from baseline) 2.1

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These metabolic changes were more prominent in cells under continuous tamoxifen treatment

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It describes the effect as dose-dependent, saying higher weekly doses correlate with stronger gastrointestinal slowdown and higher constipation rates in clinical populations