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[74] used an apoliprotein-E deficient (ApoE / ) mouse model to show the beneficial effects of liraglutide as they relate to atherosclerotic vascular disease

Additionally, future research should explore whether adjunctive therapies, such as resistance training or bone-specific pharmacologic interventions, could counteract potential bone resorption associated with weight loss or be superior to GLP-1s

All therapeutic interventions should be accompanied by motivational support, strengthening patient perceptions about their own ability and self-efficacy to self-manage diabetes [224, 225]

At 24 weeks, retatrutide 12 mg delivers 17.5% body weight loss versus an estimated 12-13% for tirzepatide 15 mg

At 24 weeks, liver-fat content (measured by non-invasive imaging, MRI-PDFF) fell by 81.4% on 8 mg and 82.4% on 12 mg, compared with a small increase in those participants on the placebo