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Resveratrol induces glutathione synthesis by activation of nuclear erythroid-related factor 2 and by decreasing oxidative stress

Oxidative stress evokes the release of inflammatory cytokines, which aggravates damage to cells and may result in apoptosis

Emerging evidence highlights a range of contributing factors, including reduced mechanical loading, increased bone marrow adiposity, hormonal and endocrine alterations, nutritional deficiencies, and disruptions in energy metabolism

Ko C, Sekijima J, Lee S

Risk factors for these complications include older age, previous ulcer disease, concurrent use of blood thinners or steroids, high doses, and prolonged use (Abdulla et al., 2013