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If possible, also track waist circumference weekly, body composition monthly (through DEXA or bioimpedance), and blood markers quarterly (fasting glucose, HbA1c, lipid panel, liver enzymes)

But your body burns through its Bs quickly, so I don't think this is the best long-term solution to feeling fatigued from eating less

36 Current evidence suggests a possible link to depressive or suicidal ideation specific to semaglutide 37, and a clearly higher incidence of gastrointestinal adverse events compared with liraglutide.38 Both remain FDA-approved and well-studied

Weight maintenance is the hardest part, however, and exercise has been shown to prevent weight regain after discontinued use of the drug

The STEP 1 clinical trial, published in the New England Journal of Medicine , found that once-weekly semaglutide produced an average body weight reduction of 14.9% over 68 weeks