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10.1074/jbc.m807061200 19 FuL.-H.WanY.QiC.HeJ.LiC.YangC.et al (2021)

A hierarchical testing procedure [2] randomized participants to subcutaneous* doses 0.4 mg, 0.2 mg, or 0.1 mg of semaglutide once daily versus placebo for 72 weeks

For context, a normal stool frequency ranges from three times a day to three times a week , according to NHS guidance on constipation

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The most common side effects include: Nausea Vomiting Stomach upset and pain Constipation Diarrhea Heartburn Acid reflux Belching Gas Dizziness Headaches Fatigue While severe side effects are rare, they can occur