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These biological changes mean that traditional weight loss programs that focus solely on calories in versus calories out may not address the underlying hormonal and metabolic factors affecting your body

Tirzepatide may lead to greater average weight loss, but "those differences are real yet secondary if you can't afford the drug or stop it because of side effects," says Srivastava

The medication may have an impact on embryo and fetal development (US FDA package insert)

For reference ATTAIN-1 reported an 11.2% body-weight loss for Orfoglipron